Here are 8 Invented Diseases Big Pharma is banking on
MARTHA ROSENBERG, ALTERNET SOURCE:- (www.peopleofthekeys.com)
03 FEB 2015
Since direct-to-consumer drug advertising debuted in 1997, pharma’s
credo has been When The Medication Is Ready, The Disease (and Patients) Will Appear. Who knew so many people suffered from restless legs? Now pharma is back to creating new diseases, patients, risks and “awareness campaigns.” Check out these eight
new diseases they’ve invented.
1. SERM deficiency
A pill to prevent postmenopausal osteoporosis packs the “magic three” of drug sales– fear, forever
and faith–since you never know if it’s working or you need it but fear stopping. But 15 years after women began swallowing bisphosphonates like Boniva and Fosamax because pharma-planted bone density machines in medical offices revealed they had
“osteopenia,”* bisphosphonates are linked to jaw bone death, esophageal cancer and causing the fractures they were supposed to prevent. Sorry about that. Now pharma is hawking Selective Estrogen Receptor Modulators (SERMs) like Evista and Tamoxifen
to prevent osteoporosis and even some cancers. Unfortunately they can cause others…
2. Statin Deficiency
seems like the whole world is on statins, it’s not your imagination. Last year the FDA approved AstraZeneca’s Crestor for children as young as 10 and in March it approved Crestor for 6.5 million people who have no cholesterol or heart problems
at all! (See: fear, forever and faith.) Many say, since lead investigator of the Justification for the Use of Statins in Primary Prevention study Paul Ridker of Brigham and Women’s Hospital in Boston is co-patent holder/inventor of the C-reactive protein
(CRP) test which “proves” Crestor’s effectiveness, there’s a conflict of interest. Others say, since CRP isn’t necessarily even a marker for heart disease and statins can cause Type 2 diabetes, it’s bad science along with a conflict of interest.)
3. Circadian Dysrhythmia
Insomnia is a gold mine for pharma because everyone sleeps — or watches TV when they can’t. But Ambien, Lunesta, Sonata and Rozerem have reached market saturation, so pharma is rolling out subcategories like nocturnal, middle-of-the-night (MOTN)
and terminal insomnia and sleep eating, sleep walking and sleep sweating (yes sweating) to boost the franchise. Meanwhile another demo is swelling Circadian Dysrhythmia numbers: Thanks to restless legs syndrome, sleep apnea, shift work sleep disorder, people
who skimp on sleep and of course insomnia meds themselves, there’s an epidemic of excessive sleepiness! Enter Provigil –”a mood-brightening and memory-enhancing psychostimulant which enhances wakefulness and vigilance,” — Adderall
and Vyvanse, known in the days of Lenny Bruce — also an “excessive sleepiness” sufferer — as speed.
4. Adult Autism, ADHD and Refusal to Play Nicey
marketed adult diseases like depression, bipolar disorder and schizophrenia in 4-year-olds to death, pharma is now finding childhood diseases in adults. Adults with ADHD have hyperactivity, impulsivity, “executive function deficits” and “difficulty
with organization and time management,” says Harvard Medical School’s Joseph Biederman, in a 2004 JAMA. The disease, found in most people’s brother-in-laws, requires “lifelong” medication says Biederman, who was accused of pushing
Risperdal and hiding pharma income by Congress in 2008. Adults may suffer from autism too says a 2008 article in Psychiatric News, if they’re “unsociable, extremely rigid, given to angry outbursts” and “acutely sensitive to light, heat,
and pain.” Luckily, in two studies “SSRI antidepressants led to a decrease in repetitive behaviors and to somewhat more socializing,” in adults with autism says Psychiatric News.
That Requires “Two Drugs”
Leave it to pharma to develop an asthma drug–the long-acting beta2-agonists (LABAs)– that triples the rate of asthma deaths, especially in African-Americans. And leave it to the FDA to
approve LABA’s on the basis of a trial, the 2003 SMART trial (Salmeterol Multicenter Asthma Research Trial), that was stopped early because of so many deaths. In March, after more deaths, especially
in children, a sheepish FDA recast LABAs as a last resort medication with or without use of a concomitant inhaled steroid. But AstraZeneca doesn’t want to stop selling its LABA with a steroid, Symbicort — and GSK its LABA with a steroid, Advair
— just because they’re correlated with death. So the LABA drugs are being billed as safe and able to treat “both” causes of asthma (see: Vytorin) and projected to earn billions this year.
6. “Treatment Resistant” Conditions
If an engine additive or laundry product didn’t work, who would chase it with another product–or two– because
the manufacturer told them to? Who would pay $300 to $900 a month out of their pocket for antidepressants, antipsychotics, mood stabilizers and mood brighteners some of which don’t work? (see: fear, forever, faith.) Increasingly, pharma is approving
drugs as add on or “adjunctive therapy” like AstraZeneca’s antipsychotic Seroquel, approved last year “for patients who had failed to respond adequately to an antidepressant alone.” Also last year, the FDA approved Eli Lilly’s
Symbyax, a combination of the SSRI antidepressant Prozac and controversial antipsychotic Zyprexa — do patients gain 100 pounds but feel great? — for “treatment resistant depression.” Why are diseases
“treatment resistant” instead of the drugs “ineffective” or diagnoses “wrong”?
7. Low T
Men are you feeling run down and
over the hill? Is your hair falling out, skin wrinkling and abdomen developing its own zip code? Have you lost interest in sex or worse, has your partner? (With you?) Do you need reading glasses, dental implants and heel splints? You’re not getting old,
you just have Low T and are ready for the aging-is-really-just-low-hormones con that women have lived with for 60 years: hormone replacement therapy. Like 50 million women before you, you can be Forever Masculine even though, to (quote hormone giant Wyeth)
you have outlived your testes if you start replacing your lost testosterone. You’ll get both kinds of zips back in your life, and it won’t change your prostate-specific antigens. Pharma promises.
8. “Spectrum” Disorders
Nothing proves pharma’s when-the-medication-is-ready credo better than the legions of people who have fibromyaglia now that Cymbalta, Savella and Lyrica are available to treat it.
Still, a “grassroots” pharma front group is conducting a Fibromyalgia Is Real awareness campaign like it did for depression and bipolar disorder, just to make sure. Pharma has also rolled out the term “depression spectrum disorder”
for fibromyalgia to make sure patients who have some but not all of the symptoms seek treatment. And speaking of spectrums, “Epilepsy Spectrum Disorder” was rolled out in January’s JAMA — a disorder which is not just about seizures
anymore but has “shared mechanisms” with “depression, autism.., and other cognitive comorbidities.” Spectrum disorders are Real–which is pharma for Reimbursable a pharma contrivance like “perimenopause” to widen the
MORE HORRORS IN WHAT WE EAT TODAY
By Far the Most Dangerous Substance Added to Most Foods Today
Samantha HemmingwayChemical "Foods", Food Crisis, Food Science, Food Toxins
Aspartame is the technical name for the brand names NutraSweet, Equal, Spoonful, and Equal-Measure. It was discovered by accident in 1965 when James Schlatter, a chemist of G.D. Searle Company, was testing an
Aspartame was approved for dry goods in 1981 and for carbonated beverages in 1983. It was originally approved for dry goods on July 26, 1974, but objections filed by neuroscience researcher Dr. John W. Olney and consumer attorney James
Turner in August 1974, as well as investigations of G.D. Searle’s research practices caused the U.S. Food and Drug Administration (FDA) to put approval of aspartame on hold (December 5, 1974). In 1985, Monsanto purchased G.D. Searle and made Searle Pharmaceuticals
and The NutraSweet Company separate subsidiaries.
Aspartame accounts for over 75 percent of the adverse
reactions to food additives reported to the FDA. Many of these reactions are very serious, including seizures and death. A few of the 90 different documented symptoms listed in the report as part of aspartame dangers are:
Loss of taste
According to researchers and physicians studying the adverse effects of aspartame, the following chronic illnesses can be triggered or worsened by ingesting of aspartame:
Chronic fatigue syndrome
Aspartame is made up of three chemicals: aspartic acid, phenylalanine,
and methanol. The bookPrescription for Nutritional Healing, by James and Phyllis Balch lists aspartame under the category of “chemical poison.” As you shall see, that is exactly what it is.
What Is Aspartame Made Of?
Aspartic Acid (40 percent of Aspartame)
Dr. Russell L. Blaylock, a professor of neurosurgery at the Medical University of Mississippi, recently published a book thoroughly detailing the damage that is caused by the ingestion of excessive
aspartic acid from aspartame. Blaylock makes use of almost 500 scientific references to show how excess free excitatory amino acids such as aspartic acid and glutamic acid (about 99 percent of monosodium glutamate or MSG is glutamic acid) in our food supply
are causing serious chronic neurological disorders and a myriad of other acute symptoms.
How Aspartate (and Glutamate) Cause Damage
Aspartate and glutamate act as neurotransmitters in the brain by facilitating the transmission
of information from neuron to neuron. Too much aspartate or glutamate in the brain kills certain neurons by allowing the influx of too much calcium into the cells. This influx triggers excessive amounts of free radicals, which kill the cells. The neural cell
damage that can be caused by excessive aspartate and glutamate is why they are referred to as “excitotoxins.” They “excite” or stimulate the neural cells to death.
Aspartic acid is an amino acid. Taken in its free form (unbound
to proteins), it significantly raises the blood plasma level of aspartate and glutamate. The excess aspartate and glutamate in the blood plasma shortly after ingesting aspartame or products with free glutamic acid (glutamate precursor) leads to a high level
of those neurotransmitters in certain areas of the brain.
The blood brain barrier (BBB), which normally protects the brain from excess glutamate and aspartate as well as toxins, 1) is not fully developed during childhood, 2) does not fully protect all
areas of the brain, 3) is damaged by numerous chronic and acute conditions, and 4) allows seepage of excess glutamate and aspartate into the brain even when intact.
The excess glutamate and aspartate slowly begin to destroy neurons. The large majority
(75 percent or more) of neural cells in a particular area of the brain are killed before any clinical symptoms of a chronic illness are noticed. A few of the many chronic illnesses that have been shown to be contributed to by long-term exposure to excitatory
amino acid damage include:
Multiple sclerosis (MS)
The risk to infants, children, pregnant women, the elderly and persons with certain chronic health problems from excitotoxins are great. Even the Federation of American Societies
for Experimental Biology (FASEB), which usually understates problems and mimics the FDA party-line, recently stated in a review that glutamic acid should be avoided by women of childbearing age.
Aspartic acid from aspartame has the same deleterious
effects on the body as glutamic acid isolated from it’s naturally protein-bound state, causing it to become a neurotoxin instead of a non-essential amino acid.
Aspartame in diet sodas, or aspartame in other liquid form are absorbed more quickly
and have been shown to spike plasma levels of aspartic acid.
The exact mechanism of acute reactions to excess free glutamate and aspartate is currently being debated. As reported to the FDA, those reactions include:
Fatigue (blocks sufficient glucose entry into brain)
One common complaint of persons suffering from the effect of aspartame is memory loss. Ironically, in 1987, G.D. Searle, the
manufacturer of aspartame, undertook a search for a drug to combat memory loss caused by excitatory amino acid damage. Blaylock is one of many scientists and physicians who are concerned about excitatory amino acid damage caused by ingestion of aspartame and
A few of the many experts who have spoken out against the damage being caused by aspartate and glutamate include Adrienne Samuels, Ph.D., an experimental psychologist specializing in research design. Another is Olney, a professor in the department
of psychiatry, School of Medicine, Washington University, a neuroscientist and researcher, and one of the world’s foremost authorities on excitotoxins. (He informed Searle in 1971 that aspartic acid caused holes in the brains of mice.)
(50 percent of aspartame)
Phenylalanine is an amino acid normally found in the brain. Persons with the genetic disorder phenylketonuria (PKU) cannot metabolize phenylalanine. This leads to dangerously high levels of phenylalanine in the brain
(sometimes lethal). It has been shown that ingesting aspartame, especially along with carbohydrates, can lead to excess levels of phenylalanine in the brain even in persons who do not have PKU.
This is not just a theory, as many people who have eaten
large amounts of aspartame over a long period of time and do not have PKU have been shown to have excessive levels of phenylalanine in the blood. Excessive levels of phenylalanine in the brain can cause the levels of serotonin in the brain to decrease, leading
to emotional disorders such as depression. It was shown in human testing that phenylalanine levels of the blood were increased significantly in human subjects who chronically used aspartame.
Even a single use of aspartame raised the blood phenylalanine
levels. In his testimony before the U.S. Congress, Dr. Louis J. Elsas showed that high blood phenylalanine can be concentrated in parts of the brain and is especially dangerous for infants and fetuses. He also showed that phenylalanine is metabolized much
more efficiently by rodents than by humans.
One account of a case of extremely high phenylalanine levels caused by aspartame was recently published by the Wednesday Journal in an article titled “An Aspartame Nightmare.” John Cook began drinking
six to eight diet drinks every day. His symptoms started out as memory loss and frequent headaches. He began to crave more aspartame-sweetened drinks. His condition deteriorated so much that he experienced wide mood swings and violent rages. Even though he
did not suffer from PKU, a blood test revealed a phenylalanine level of 80 mg/dl. He also showed abnormal brain function and brain damage. After he kicked his aspartame habit, his symptoms improved dramatically.
As Blaylock points out in his book, early
studies measuring phenylalanine buildup in the brain were flawed. Investigators who measured specific brain regions and not the average throughout the brain notice significant rises in phenylalanine levels. Specifically the hypothalamus, medulla oblongata,
and corpus striatum areas of the brain had the largest increases in phenylalanine. Blaylock goes on to point out that excessive buildup of phenylalanine in the brain can cause schizophrenia or make one more susceptible to seizures.
excessive use of aspartame may provide a boost to sales of serotonin reuptake inhibitors such as Prozac and drugs to control schizophrenia and seizures.
Methanol a.k.a wood alcohol/poison (10 percent of aspartame)
alcohol is a deadly poison. Some people may remember methanol as the poison that has caused some “skid row” alcoholics to end up blind or dead. Methanol is gradually released in the small intestine when the methyl group of aspartame encounters
the enzyme chymotrypsin.
The absorption of methanol into the body is sped up considerably when free methanol is ingested. Free methanol is created from aspartame when it is heated to above 86 Fahrenheit (30 Centigrade). This would occur when aspartame-containing
product is improperly stored or when it is heated (e.g. as part of a “food” product such as Jello).
Methanol breaks down into formaldehyde in the body. Formaldehyde is a deadly neurotoxin. An EPA assessment of methanol states that methanol
“is considered a cumulative poison due to the low rate of excretion once it is absorbed. In the body, methanol is oxidized to formaldehyde.” They recommend a limit of consumption of 7.8 mg/day. A one-liter (approx. 1 quart) aspartame-sweetened
beverage contains about 56 mg of methanol. Heavy users of aspartame-containing products consume as much as 250 mg of methanol daily or 32 times the EPA limit.
Symptoms from methanol poisoning include headaches, ear buzzing, dizziness, nausea, gastrointestinal
disturbances, weakness, vertigo, chills, memory lapses, numbness and shooting pains in the extremities, behavioral disturbances, and neuritis. The most well known problems from methanol poisoning are vision problems including misty vision, progressive contraction
of visual fields, blurring of vision, obscuration of vision, retinal damage, and blindness. Formaldehyde is a known carcinogen, causes retinal damage, interferes with DNA replication and causes birth defects.
Due to the lack of a couple of key enzymes,
humans are many times more sensitive to the toxic effects of methanol than animals. Therefore, tests of aspartame or methanol on animals do not accurately reflect the danger for humans. As pointed out by Dr. Woodrow C. Monte, director of the food science and
nutrition laboratory at Arizona State University: “There are no human or mammalian studies to evaluate the possible mutagenic, teratogenic or carcinogenic effects of chronic administration of methyl alcohol.”
He was so concerned about the
unresolved safety issues that he filed suit with the FDA requesting a hearing to address these issues. He asked the FDA to:
“…[S]low down on this soft drink issue long enough to answer some of the important questions. It’s not
fair that you are leaving the full burden of proof on the few of us who are concerned and have such limited resources. You must remember that you are the American public’s last defense. Once you allow usage (of aspartame) there is literally nothing I
or my colleagues can do to reverse the course. Aspartame will then join saccharin, the sulfiting agents, and God knows how many other questionable compounds enjoined to insult the human constitution with governmental approval.”
the Commissioner of the FDA, Arthur Hull Hayes, Jr., approved the use of aspartame in carbonated beverage. He then left for a position with G.D. Searle’s public relations firm.
It has been pointed out that some fruit juices and alcoholic beverages
contain small amounts of methanol. It is important to remember, however, that methanol never appears alone. In every case, ethanol is present, usually in much higher amounts. Ethanol is an antidote for methanol toxicity in humans. The troops of Desert Storm
were “treated” to large amounts of aspartame-sweetened beverages, which had been heated to over 86 degrees F in the Saudi Arabian sun. Many of them returned home with numerous disorders similar to what has been seen in persons who have been chemically
poisoned by formaldehyde. The free methanol in the beverages may have been a contributing factor in these illnesses. Other breakdown products of aspartame such as DKP (discussed below) may also have been a factor.
In a 1993 act that can only be described
as “unconscionable,” the FDA approved aspartame as an ingredient in numerous food items that would always be heated to above 86 degree F (30 degree C).
DKP is a byproduct of aspartame metabolism.
DKP has been implicated in the occurrence of brain tumors. Olney noticed that DKP, when nitrosated in the gut, produced a compound that was similar to N-nitrosourea, a powerful brain tumor causing chemical. Some authors have said that DKP is produced after
aspartame ingestion. I am not sure if that is correct. It is definitely true that DKP is formed in liquid aspartame-containing products during prolonged storage.
G.D. Searle conducted animal experiments on the safety of DKP. The FDA found numerous experimental
errors occurred, including “clerical errors, mixed-up animals, animals not getting drugs they were supposed to get, pathological specimens lost because of improper handling,” and many other errors. These sloppy laboratory procedures may explain
why both the test and control animals had 16 times more brain tumors than would be expected in experiments of this length.
In an ironic twist, shortly after these experimental errors were discovered, the FDA used guidelines recommended by G.D. Searle
to develop the industry-wide FDA standards for good laboratory practices.
DKP has also been implicated as a cause of uterine polyps and changes in blood cholesterol by FDA Toxicologist Dr. Jacqueline Verrett in her testimony before the U.S. Senate.